Comparison of a dengue-2 virus and its candidate vaccine derivative: Sequence relationships with the flaviviruses and other viruses
Identifieur interne : 001F58 ( Main/Exploration ); précédent : 001F57; suivant : 001F59Comparison of a dengue-2 virus and its candidate vaccine derivative: Sequence relationships with the flaviviruses and other viruses
Auteurs : J. Blok [Australie] ; S. M. Mcwilliam [Australie] ; H. C. Butler [Australie] ; A. J. Gibbs [Australie] ; G. Weiller [Australie] ; B. L. Herring [Australie] ; A. C. Hemsley [Australie] ; J. G. Aaskov [Australie] ; S. Yoksan [Thaïlande] ; N. Bhamarapravati [Thaïlande]Source :
- Virology [ 0042-6822 ] ; 1992.
English descriptors
- Teeft :
- Academic press, Acid, Amino, Amino acid changes, Amino acid differences, Amino acid residues, Amino acid sequence, Amino acid sequences, Amino acid substitutions, Amino acids, Asibi, Attenuated, Avirulent, Biol, Black beetle nodavirus, Blok, Bruenn, Cdna, Cdna clones, Cdna synthesis, Clone, Comparative analysis, Complete nucleotide sequence, D2pdk, D2sl, Dendrogram, Dendrograms, Dengue, Dengue serotypes, Dengue type, Dengue virus, Dengue viruses, Distance measures, Dpjam, Dpngc, Encephalitis, Encephalitis virus, Feng, Flavivirus, Flavivirus proteins, Flavivirus tree, Flavivirus west nile virus, Full names, Genes coding, Genetic recombination, Genome, Glycoprotein, Immunization, Japanese encephalitis, Mandl, Monoclonal, Monoclonal antibodies, Mosaic, Murray valley encephalitis, Nonstructural, Nonstructural proteins, Nonvirion proteins, Ns2a, Ns2b, Ns4a, Ns4b, Nucleic, Nucleic acids, Nucleotide, Nucleotide changes, Nucleotide differences, Nucleotide sequence, Nucleotide sequences, Oligonucleotide, Other flaviviruses, Other viruses, Partial nucleotide sequence, Polymerase, Positive strand, Primer, Proc, Protein, Protein sequences, Room temperature, Scale divisions, Scale units, Schlesinger, Sequence analysis, Sequence data, Sequencing, Sister group, Structural proteins, Substitution, Swissprot database, Tree method, Trent, Vaccine, Viral, Virion, Virion proteins, Virology, Virulent, Virus, Wengler, Yellow fever, Yellow fever virus, Yoksan.
Abstract
Abstract: A comparison of the sequence of the dengue-2 16681 virus with that of the candidate vaccine strain (16681-PDK53) derived from it identified 53 of the 10,723 nucleotides which differed between the strains. Nucleotide changes occurred in genes coding for all virion and nonvirion proteins, and in the 5′ and 3′ untranslated regions. Twenty-seven of the nucleotide changes resulted in amino acid alterations. The greatest amino acid sequence differences in the virion proteins occurred in prM (2.20%; 291 amino acids) followed by the M protein (1.33%; 175 amino acids), the C protein (0.88%; 1114 amino acid), and the E protein (0.61%; 3495 amino acids). Differences in the amino acid sequence of nonvirion proteins ranged from 1.51% (6398 amino acids) in NS4 to 0.33% (3900 amino acids) in NS5. The encoded protein sequences of 16681-PDK53 were also compared with the published sequences of other flaviviruses to obtain a detailed classification of 17 flaviviruses using the neighbor-joining tree method. The analyses of the sequence data produced dendrograms which supported the traditional groupings based on serological evidence, and they suggested that the flaviviruses have evolved by divergent mutational change and there was no evidence of genetic recombination between members of the group. Comparisons of the sequences of the flavivirus polymerase and helicase-like proteins (NS5 and NS3, respectively) with those from other viruses yielded a classification of the flaviviruses indicating that the primary division of the flaviviruses was between those transmitted by mosquitoes and those transmitted by ticks.
Url:
DOI: 10.1016/0042-6822(92)90460-7
Affiliations:
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Nucleotide changes occurred in genes coding for all virion and nonvirion proteins, and in the 5′ and 3′ untranslated regions. Twenty-seven of the nucleotide changes resulted in amino acid alterations. The greatest amino acid sequence differences in the virion proteins occurred in prM (2.20%; 291 amino acids) followed by the M protein (1.33%; 175 amino acids), the C protein (0.88%; 1114 amino acid), and the E protein (0.61%; 3495 amino acids). Differences in the amino acid sequence of nonvirion proteins ranged from 1.51% (6398 amino acids) in NS4 to 0.33% (3900 amino acids) in NS5. The encoded protein sequences of 16681-PDK53 were also compared with the published sequences of other flaviviruses to obtain a detailed classification of 17 flaviviruses using the neighbor-joining tree method. The analyses of the sequence data produced dendrograms which supported the traditional groupings based on serological evidence, and they suggested that the flaviviruses have evolved by divergent mutational change and there was no evidence of genetic recombination between members of the group. Comparisons of the sequences of the flavivirus polymerase and helicase-like proteins (NS5 and NS3, respectively) with those from other viruses yielded a classification of the flaviviruses indicating that the primary division of the flaviviruses was between those transmitted by mosquitoes and those transmitted by ticks.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Thaïlande</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Blok, J" sort="Blok, J" uniqKey="Blok J" first="J." last="Blok">J. Blok</name></noRegion><name sortKey="Aaskov, J G" sort="Aaskov, J G" uniqKey="Aaskov J" first="J. G." last="Aaskov">J. G. Aaskov</name><name sortKey="Butler, H C" sort="Butler, H C" uniqKey="Butler H" first="H. C." last="Butler">H. C. Butler</name><name sortKey="Gibbs, A J" sort="Gibbs, A J" uniqKey="Gibbs A" first="A. J." last="Gibbs">A. J. Gibbs</name><name sortKey="Hemsley, A C" sort="Hemsley, A C" uniqKey="Hemsley A" first="A. C." last="Hemsley">A. C. Hemsley</name><name sortKey="Herring, B L" sort="Herring, B L" uniqKey="Herring B" first="B. L." last="Herring">B. L. Herring</name><name sortKey="Mcwilliam, S M" sort="Mcwilliam, S M" uniqKey="Mcwilliam S" first="S. M." last="Mcwilliam">S. M. Mcwilliam</name><name sortKey="Mcwilliam, S M" sort="Mcwilliam, S M" uniqKey="Mcwilliam S" first="S. M." last="Mcwilliam">S. M. Mcwilliam</name><name sortKey="Weiller, G" sort="Weiller, G" uniqKey="Weiller G" first="G." last="Weiller">G. Weiller</name></country><country name="Thaïlande"><noRegion><name sortKey="Yoksan, S" sort="Yoksan, S" uniqKey="Yoksan S" first="S." last="Yoksan">S. Yoksan</name></noRegion><name sortKey="Bhamarapravati, N" sort="Bhamarapravati, N" uniqKey="Bhamarapravati N" first="N." last="Bhamarapravati">N. Bhamarapravati</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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